Dr. Holford’s talk will focus on modeling in clinical pharmacology. Like many disciplines, clinical pharmacology can be viewed from several perspectives. In the context of a clinical trial of a therapeutic agent, clinical pharmacology provides a conceptual framework for relating drug treatment to responses and differentiating possible mechanisms of action.  Disease progression refers to the evolution of a disease over time. It typically implies worsening of the disease (but also may include spontaneous recovery). Disease progress on the other hand is a description of the disease and its response to treatment. In the context of simulation and modeling, it is useful to think of clinical pharmacology as a model itself, i.e., the combination of disease progression and drug action.

 

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