Peer Reviewed Journal Publication

Vincent Hurez, Glenn Gauderat, Perrine Soret, Renee Myers, Krishnakant Dasika, Robert Sheehan, Christina Friedrich, Mike Reed, Laurence Laigle, Marta Alarcón Riquelme, Audrey Aussy, Loubna Chadli, Sandra Hubert, Emiko Desvaux, Sylvain Fouliard, Philippe Moingeon and the PRECISESADS Clinical Consortium

Virtual patients inspired by multiomics predict the efficacy of an anti-IFNα mAb in cutaneous lupus

Highlights • QSP modeling of lupus can be used to predict the efficacy of drug candidates. • A cohort of virtual lupus patients was created from profiling data of actual patients. • Virtual patient simulations predicted distinct anti IFN treatment responses. • Machine learning found biomarkers to differentiate responders from non-responders.

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Poster

Tomohiro Sasaki, Christina Friedrich, Krishnakant Dasika, Vincent Hurez, Renee Myers, Lesley Benyon, Miyuki Yuasa, Emiri O Takaki, Kazuhide Nakamura, Yosuke Kawai

QSP modeling of OPB-171775, a phosphodiesterase 3A–Schlafen 12 molecular glue, to predict clinical responses in patients with gastrointestinal stromal tumors

Presented by Otsuka Pharmaceutical Co. Ltd. and Rosa at PAGE 2025 in Thessaloniki, Greece

Poster

Alvaro Ruiz-Martinez, Rebecca Baillie, Renee Myers, Robert Sheehan, Jakob Kisbye Dreyer, Frederik Rode, Lene Hansen, Mike Reed

Accurate modeling of ACTH and cortisol dynamics for Cushing’s disease treatment

Presented by Rosa in collaboration with Lundbeck at ACoP 2025 in Denver, CO, USA.

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Poster

Renee Myers, Alvaro Ruiz-Martinez, Mike Reed

Evaluation of Parallel Tempering for Efficient Generation of Virtual Populations

Presented by Rosa at ACoP 2025 in Denver, CO, USA.

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Poster

Alvaro Ruiz-Martinez, Colleen Witt, Christina Friedrich, Lesley Benyon, Nadine Defranoux, Panteleimon Mavroudis, Bill McCarty, Mike Reed, Majid Vakilynejad

Adaptable PBPK-QSP gene therapy model applied to i.v. administration of AAV-2 across different species

Presented by Rosa in collaboration with Sanofi at ACoP 2025 in Denver, CO, USA.

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