Conference Presentation

Christina Friedrich

How does QSP modeling support R&D decisions? Case examples of modeling impact in central nervous system and inflammatory diseases.

Presented at the AAPS PharmSci360 Conference, November 2019

Poster

Mike Reed, Michael Weis, Rebecca Baillie, Thomas Klabunde, Hans Christoph Schneider, Markus Rehberg, Lothar Schwink

Investigating GPR119 agonist efficacy in a systems pharmacology model of diabetes

Presented by Sanofi and Rosa at the American Conference on Pharmacometrics (ACoP), October 2019

Poster

Maria Trujillo; Rebecca Baillie; Michael Weis; Douglas Chung; Michael Reed; Geoffrey Walford; Jennifer Abrams; Paul Carrington

Leveraging a Diabetes QSP Model to Drive Decisions in Target ID and Validation for a Proinsulin Program

Presented by Merck and Rosa at the American Conference on Pharmacometrics (ACoP), October 2019

Poster

Douglas Chung, Michael Weis, Christina Friedrich, Vincent Hurez, Rebecca Baillie, Katherine Kudrycki

Development of a mechanistic representation of a stable solid tumor

Presented by Rosa at the American Conference on Pharmacometrics (ACoP), October 2019

Poster

Christina Friedrich, Ron Beaver

A qualitative and quantitative framework to assess the value of QSP modeling in pharmaceutical development.

Presented by Rosa at the American Conference on Pharmacometrics (ACoP), October 2019

Conference Presentation

Christina Friedrich

Using QSP modeling to support pediatric drug development: case studies in bile acids and immuno-oncology

Presented at the American Conference on Pharmacometrics (ACoP), October 2019

Poster

Christina Friedrich, Takashi Ito, Katherine Kudrycki, Meghan Pryor, Vincent Hurez , Shinnosuke Yamada, Naoki Kiyosawa, Masatoshi Nishimura, Ryo Atsumi, Kiyoshi Morimoto

A simulation study for clinical efficacy of an anti ORAI1 antibody (DS 2741a) on atopic dermatitis using QSP modeling for preclinical to clinical translation

Presented by Daiichi Sankyo and Rosa at the 28th European Academy of Dermatology and Venereology (EADV) Congress (2019)

Poster

V. Hurez, M. Weis, R. Baillie, M. Reed, M. Rehberg, K. Beuke, A. Dietrich, B. Göbel, N. Biesemann, C. Asbrand, A. Subramaniam, W. Seiz, M. Herrmann, T. Klabunde, F. Nestle

Evaluation of competitive differentiation of novel therapies and the impact of patient variability on efficacy in a psoriasis QSP platform

Presented by Sanofi and Rosa at at the Population Approach Group in Europe Conference (PAGE), 2019

Peer Reviewed Journal Publication

Saroja Ramanujan, Jason R. Chan , Christina M. Friedrich , Craig J. Thalhauser

A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

Published in CPT: Pharmacometrics & Systems Pharmacology, Apr. 14, 2019.

Peer Reviewed Journal Publication

Michael Weis, Rebecca Baillie, and Christina Friedrich

Considerations for Adapting Pre-existing Mechanistic Quantitative Systems Pharmacology Models for New Research Contexts

Published in Frontiers in Pharmacology, Apr. 18, 2019.

Poster

Mike Reed, Michael Weis, Rebecca Baillie, Hans-Christoph Schneider, Thomas Klabunde

Incorporation of Renal SGLT Function into a Quantitative Systems Pharmacology (QSP) Model

Presented by Sanofi and Rosa at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) conference, 2019.

Poster

V. Hurez, M. Weis, R. Baillie, M. Rehberg, K. Beuke, N. Biesemann, C. Asbrand, T. Klabunde, M. Herrmann, M. Reed

Evaluation of Novel Anti-TNFα and IL-6R Therapies in a Rheumatoid Arthritis (RA) Quantitative Systems Pharmacology (QSP) Platform

Presented by Sanofi and Rosa at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) conference, 2019.

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